Pagetoid Premalignant Melanosis And Melanoma: Differentiation From Hutchinson's Melanotic Freckle

Suppression of malignancy and differentiation in melanotic melanoma cells.

Tumorigenicity of mouse melanoma cells is reduced or lost upon growth in vitro in 1 to 3 mug/ml of 5-bromodeoxyuridine (BUdR). The rate of growth is very little affected by these concentrations. The morphology of the cells is altered, such that the cells grow in a flattened, often fibroblastic monolayer, showing contact inhibition, instead of the rounded, multilayered mounds characteristic of t...

Melanotic Sarcoma and "Sarcomatous Melanoma"

Impression cytology of conjunctival melanosis and melanoma.

Impression cytology using cellulose acetate paper has been used in various ocular surface disorders as a simple non-invasive diagnostic test. To assess its value in differentiating melanocytic tumours, 24 patients with a range of pigmented lesions of the conjunctiva were examined using this technique. Cytological and histological diagnoses were compared in 23 cases. In 73% of cases impression c...

Neurocutaneous melanosis presenting with intracranial amelanotic melanoma.

We describe imaging findings in a 2-year-old girl with neurocutaneous melanosis and malignant cerebral melanoma. Because the cerebral melanoma in this child was of the amelanotic type, high-signal intensity on unenhanced T1-weighted images was not present. The cutaneous lesions played a crucial role in establishing a correct (presumed) histopathologic diagnosis on the basis of the imaging findi...

Neurocutaneous Melanosis with Malignant Leptomeningeal Melanoma

Neurocutaneous melanosis (NCM) is a rare congenital syndrome characterized by the presence of large or multiple congenital melanocytic nevi with either benign or malignant pigmented cell tumors of the leptomeninges. We report a case of NCM in a patient with previously robust health. No neurological deficit was noted in the patient. At the age of 21 years old, blurred vision initially appeared. ...